The Top Ten Violence Inducing Prescription Drugs.

[kb2vxa]

I feel depressed, I feel so bad
But you're the best pill that I ever had
I can't get your love, I can't get a fraction
Uh-oh, little pill, psychotic reaction
(shouted) And it feels like this!

I can't seem to face up to the facts
I'm tense and nervous and I
Can't relax
I can't sleep 'cause my bed's on fire
Don't touch me I'm a real live wire

Psycho Killer
Qu'est-ce que c'est
fa fa fa fa fa fa fa fa fa far better
Run run run run run run run away
Psycho Killer
Qu'est-ce que c'est
fa fa fa fa fa fa fa fa fa far better
Run run run run run run run away

One pill makes you larger
And one pill makes you small
And the ones that mother gives you
Don't do anything at all
Go ask Alice
When she's ten feet tall

Well, you get the idea...................

[KG4CGC]

@John:

I said that Prozac is a speedball not an SSRI. I said most all of those drugs are SSRI, not all.

[n2ize]

@John:

I said that Prozac is a speedball not an SSRI. I said most all of those drugs are SSRI, not all.

"Speedball" is a slang term for a mixture of heroin and cocaine either mixed or used concomitantly. It has also been used in days gone by for mixtures of stimulants and depressants, i.e. amphetamines and barbiturates, speed and librium or valium, etc.

Prozac is a "Selective Serotonin Reuptake Inhibitor" because it targets specific serotonin sites and doesn't allow reuptake to occur thus causing a buildup of serotonin in the brain which is supposed to help alleviate symptoms such as depression, anxiety disorder, panic attacks, etc.

Cocaine doesn't act this way. Cocaine is a CNS stimulant and can even cause panic attacks in certain people. It is not a SSRI. I believe it affect dopamine receptors and it can also cause the brain to produce more opiate receptors thus making opiates less effective over time. Unlike cocaine heroin is a CNS depressant. it binds to specific opiate receptors. Neither of these 2 drugs is an SSRI as they do not selectively target serotonin receptors. Of course cocaine is also a local anesthetic. Anyone who has ever tried using it via the nasal route has probably noticed that it eventually numbs the back of the nose and the two upper front teeth. And it can work wonders for a bad toothache. Heck it should be legal just for that purpose.

However I am interested as to whether either of these 2 drugs, opiates and cocaine, do inhibit serotonin reuptake to some small or moderate degree. Unfortunately I cannot find any studies or descriptions that say that they do. I was hoping you might be able to point me to something.

On the other hand Prozac is most definitely an SSRI. It was specifically designed to be an SSRI.

[KG4CGC]

John, you always have a way of clouding every damn issue someone tries to discuss with you. Look beyond what you read in a book or look up on wiki and consider what is actually happening to a person who takes Prozac.
You couldn't possibly understand what I'm talking about because you will not even accept it as a possibility.

[n2ize]

John, you always have a way of clouding every damn issue someone tries to discuss with you. Look beyond what you read in a book or look up on wiki and consider what is actually happening to a person who takes Prozac.
You couldn't possibly understand what I'm talking about because you will not even accept it as a possibility.

When a person takes Prozac the serotinin receptors in their brain are blocked from re-uptake causing a buildup of serotonin in the brain which is supposed to reduce depression and anxiety. Cocaine and heroin work differently and have different effect, Persons whom I know who have taken Prozac do not get the same kind of CNS depression and euphoria that heroin produces because Prozac and heroin work differently inside the brain. Heroin is metabolized into morphine which , unlike Prozac then binds to opiate receptors where it mimics natural endorphines. The essential mechanisms regarding heroin, cocaine and Prozac are well known to science.

You stated that Heroin, cocaine and Prozac are all "selective serotonin uptake receptors" (SSRI's) and I am saying that I cannot ascertain that fact from any of the pharmacological literature that I presently have at my disposal. Nor can I ascertain that based on effects because all three of the drugs in question (two of which I have used in my lifetime) have very significant differences in terms of formula, and physical and psychological effects i.e. the way they make you feel thus indicating that all three act upon the brain and CNS differently. These facts correlate with pharmaceutical science. All I would appreciate is if you can point me to a piece of pharmacological literature that indicates they all act as SSRI's and/or cause some degree of serotonin reuptake inhibition because I cannot find anything so far.

And sorry, when it comes to such thin gs as the mechanisms behind how drugs work in the brain I like to base things on scientific research as opposed to assumption. perhaps that makes me ignorant or stupid and perhaps I am a very stupid man. If so,, then so be it. My ignorance and stupidity and my reliance on science has managed to work well for me so I'll stick with it and remain stupid.

[KG4CGC]

You stated that Heroin, cocaine and Prozac are all "selective serotonin uptake receptors"

Wrong. Never said that.
Please pay attention to the main point. Prozac contains a molecular make up of one or more substances that are analogous to cocaine and heroin.

(SSRI's) and I am saying that I cannot ascertain that fact from any of the pharmacological literature that I presently have at my disposal.

No pharmaceutical company in their right might mind would ever admit to any similarities.

have very significant differences in terms of formula, and physical and psychological effects i.e. the way they make you feel thus indicating that all three act upon the brain and CNS differently. These facts correlate with pharmaceutical science.

See above.

All I would appreciate is if you can point me to a piece of pharmacological literature that indicates they all act as SSRI's and/or cause some degree of serotonin reuptake inhibition because I cannot find anything so far.

There is no scientific study to say so. See above. You must break the capsule open yourself and subject it to your own personal testing. The effects of a speedball are not as profound but are a speedball none the less.

And sorry, when it comes to such thin gs as the mechanisms behind how drugs work in the brain I like to base things on scientific research as opposed to assumption. perhaps that makes me ignorant or stupid and perhaps I am a very stupid man. If so,, then so be it. My ignorance and stupidity and my reliance on science has managed to work well for me so I'll stick with it and remain stupid.

Now you're just getting personal. You want to argue the point as if we were in a courtroom but I'm saying that the side effects brought on by Prozac are part of its molecular analogous nature to two popular illegal drugs and again, no big pharma company will ever admit that.

Most of these SSRIs over do what they are supposed to do. Basically, drug companies are just guessing and trying to see what works best. The other side effects of raised blood pressure and other heart conditions should start to raise a few questions about CNS stimulation.

Pristiq is another one with dual effects.

serotonin-norepinephrine reuptake inhibitors, or SNRIs for short. SNRIs act on specific chemicals within the brain known as serotonin and norepinephrine. These are two of several chemicals used to send messages from one nerve cell to another.

Norepinephrine is a known chemical in the brain that gets excited by people who ingest speed and or coke. This is a drug that was developed with former stimulant abusers in mind but, it doesn't really correct the chemical transfer in the synapses to a pre-abuse time in the person taking the drug, Pristiq. Targeting serotonin and other such related brain chemicals will soon fall out of favor, but not until the drug companies have exploited this path for as long as possible. Afterall, we're talking 1980's science that has since been proven to be ineffective for most people seeking relief from some sort of ill feelings. Yes, it works for a few people but like other drugs in the past, they are being over prescribed.

Balancing the way your blood handles oxygen and the oxygen levels in your brain will prove more fruitful in treating common ''depression'' in the future but until then, they drug companies will stay on the lucrative road they're on.

[N2NH]

Well Ritalin is prescribed to 6 million Americans and it is similar to Cocaine. That much is fact.

As far as Prozac and Coke:

Earlier generations of serotonin-targeting drugs like cocaine, amphetamines, diet pills, and Ecstasy “have been exhaustively studied in animals, and all have been shown to be neurotoxic to cells in the brain—for example, destroying nerve endings. But there’s very little comparable research on the SSRIs,” Glenmullen says. “To do animal research, you need tiny doses of the pure drug. Yet researchers say that each pharmaceutical company controls the supply of pure drug while it is under patent. To do studies under a company’s auspices means signing a contract that allows it to veto publication unilaterally.”

SCIENCE! LINK

I'm quite certain nobody was well aware of that. Crafty bugger.

[KG4CGC]

Well Ritalin is prescribed to 6 million Americans and it is similar to Cocaine. That much is fact.

It's a great buzz too.

[N2NH]

It's a great buzz too.

Now, now Charles, that isn't the scientific term is it?

It's gives a great feeling of enthusiasm/euphoria. Just sayin, ya know. The way they say it north of here.

[n2ize]

Wrong. Never said that.
Please pay attention to the main point. Prozac contains a molecular make up of one or more substances that are analogous to cocaine and heroin.

No pharmaceutical company in their right might mind would ever admit to any similarities.

In organic chemistry many drugs and compounds have structural similarities between each other. There are various benzine rings in different configurations, methyl groups, acetyl groups. matter of fact many drugs belon to the same classes of compounds, i.e. esters, alcohols, etc. However, just because similar structures exists within different molecules does not mean they act the same way when places in the blood stream or when they cross the blood brain barrier. Minor changes can radically alter the manner in which a given druigs reacts.

There is no scientific study to say so. See above. You must break the capsule open yourself and subject it to your own personal testing. The effects of a speedball are not as profound but are a speedball none the less.

Again "speedball" is a slang term. A "speedball" effect is a combined effect. You get a stimulating jag from the stimulant drug in the speedball and you get the smoothed out mellowness of the depressant. it's actually a pretty cool high, i used to dig it years ago. it is also dangerous because the cocaine constricts your blood vessels requiring increased heart output but the depressant is slowing the heart making the chances of a heart attack more likely. However, just because some people may seem to get a "speedball" effect when they use Prozac in certain ways.

Now you're just getting personal. You want to argue the point as if we were in a courtroom but I'm saying that the side effects brought on by Prozac are part of its molecular analogous nature to two popular illegal drugs and again, no big pharma company will ever admit that.

They don't have to admit it. Any organic chemistry student can look up the formulas and structural models for prozac, heroin and cocaine and they will see that there are various common organic components present in each of these drugs. At the same time the student will also see that these common organic structures are arranged quite differently in each of the three drugsnand will realize they probably exert different effects. Cocaine and heroin both have benzine rings yet one is a stimulant and one a depressant Morphine for example has -OH radicals attached and so does alcohol. Yet they work differently.

Most of these SSRIs over do what they are supposed to do. Basically, drug companies are just guessing and trying to see what works best. The other side effects of raised blood pressure and other heart conditions should start to raise a few questions about CNS stimulation.

All drugs have varying side effects. Just because a drug may cause CNS stimulation does not automatically make it like cocaine. Certain antibiotics can give false positives for opiates. But that doesn't mean there is opium in them. NSAID's can increase blood pressure a d cause anxieties. But that doesn't mean they are speed. Allergy medicines can cause sleepiness but that doesn't mean they work like morphine in the brain.

Pristiq is another one with dual effects.
Norepinephrine is a known chemical in the brain that gets excited by people who ingest speed and or coke. This is a drug that was developed with former stimulant abusers in mind but, it doesn't really correct the chemical transfer in the synapses to a pre-abuse time in the person taking the drug, Pristiq. Targeting serotonin and other such related brain chemicals will soon fall out of favor, but not until the drug companies have exploited this path for as long as possible. Afterall, we're talking 1980's science that has since been proven to be ineffective for most people seeking relief from some sort of ill feelings. Yes, it works for a few people but like other drugs in the past, they are being over prescribed.

Actually many of these compounds have been proved very effective. Many people with depression and severe panic disorders can now live normal lives because of these drugs. Where they were once confined to the home and living in constant fear of an attack they can now hold jobs, go out with friends, and live normal lives. The same holds true for many antipsychotic medicines. True they may have unpleasant side effects but many people taking them can live relatively normal lives where as at one time they would have been confined to a sanitarium in a vegitative state does up on Haldol or Thorazine.

Pharmaceutical research is an ongoing developmental process involving various disciplines such as biological-psychology (understanding the bio-chemical nature of brain functions and disorders),and many other specialties. As the research evolves there is no doubt that new drugs may be developed, perhaps improved versions of SSRI's or maybe entirely hew drugs that work on different parts of the brain with fewer side effects.

In any event it;s an ongoing process. It's not just a haphazard, guesswork and "shot in the dark" process. It is a gradual and painstaking evolutionary type of research that involves countess hours of research, experimentation, more research, experimentation, testing, etc.

As a person who worked in the Pharmaceuticaal industry I can tell you. Although I wasn't a drugmaker I did learn that a heck of a lot of intense and dedicated research and hard work and intensive testing goes into every pill that ends up dispensed at the pharmacy. it is by no means a crapshoot. There is a heck of a lot of expertise behind the scenes.

Balancing the way your blood handles oxygen and the oxygen levels in your brain will prove more fruitful in treating common ''depression'' in the future but until then, they drug companies will stay on the lucrative road they're on.

Perhaps this will be true. Time will tell.