Gotta give a +1 to this comment, and the VHF/UHF weak-signal enthusiast should definitely include 6M along with 222MHz (if at all possible) in his or her station lineup.
General ragchewing and DXing activities on 50MHz and up are fun in their own right - but what really makes the bands shine are contests. Especially during a sunspot peak (6M), ducting event (2M and up) or meteor/auroral event (all of the VHF spectrum).